Comorbid CAD and Ventricular Hypertrophy Compromise The Perfusion of Myocardial Tissue at Subcritical Stenosis of Epicardial Coronaries

BACKGROUND: Most studies of CAD revascularization have been based on and reported according to angiographic criteria which don’t consider the relation between the resulting effective flow distal to the stenosis and the demand of a hypertrophied myocardial tissue. MODEL: Mathematical model of the myocardial perfusion in comorbid CAD and ventricular hypertrophy using Poiseuille’s law. The analysis yields that the curve, which represents the relation between the perfusion and the severity of CAD depending on angiographic and/or angiophysiologic criteria, is shifted to the right by the effect of myocardial tissue hypertrophy. The right shift of said curve, which is directly proportional to the degree of ventricular hypertrophy, indicates that the perfusion of the corresponding myocardial tissue is compromised at angiographically and/or angiophysiologically subsignificant stenosis of the supplying epicardial